[36GoudeyMan]

Best guess, other than the generally accepted Ruth/Gehrig/Cobb triad, would be for well-centered, mid-grade Cy Young, Nap Lajoie, Walter Johnson and Eddie Plank cards from mainstream sets like T206, Cracker Jacks, etc.

Also, some specific sets have cards that I think have potential over 5-10 years, such as Diamond Stars Bill Dickey, low # and high # cards, in higher grade, the #1 Lefty Grove card in high grade, 1934 Goudey Foxx, 1938 Goudey Feller, and many others similarly situated in mainstream sets.

There's resources out there, like the top 100 or 200 cards in the hobby, that can give you guidance on what is viewed by some/many as the most desirable or valuable cards, many of which an be had for under $10,000 in very desirable shape.

Good luck!!