Very little in terms of my appreciation of the card, but I'm aware of what effect centering has for other collectors so I factor it into what I'm willing to bid.
My understanding is that the aesthetic preference for symmetry in objects is probably just a side effect of evolved adaptations for preferring mates with more symmetrical faces, and I'm happy not to be beholden to that side effect when I can save some money on a card I want to keep in my long-term personal collection.
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