I think the Wagner and Mantle are no-brainers.
From there I think you have to include the 1989 Upper Deck Griffey. It's the premier modern card and has defined an era.
Honestly if I had to pick a 4th card, it might be the 2001 Bowman Chrome Albert Pujols Autograph. It changed the hobby. And while vintage collectors might not want to hear it, it's as big a deal for modern collectors as pretty much any card would be for a vintage collector.
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