I think early cards and memorabilia of superstars from that long gap between actual card sets is a good buy right now. I've been salting away unusual regional cards, team issue cards, and related items for years. Thing is, they are so hard to find that you cannot amass a really large group. Also what makes them fun. This is a 1960 Boston TI:
Photos are a good area too, though they have been on fire lately. I just consigned some Russell-Chamberlain early photos that i've been holding for years. This one I hung on to, it is a favorite. 1961: