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John H.I always seem to see more #1's available than #250's so I'm kind of surprised by the comments in this thread. The #1 card in any set always carries a bit of a premium so that may explain the difference in book prices. Whatever the case, I prefer #250 because of the bright yellow background and the classic closeup photo, even though it was used again by Topps in '55 and '56 and countless other times in other places. #1 has also been reprinted a few times while #250 has only been redone once, so there are many more versions of #1 on the market.
John