I used to focus on HOF rookies but then I got really interested in pre-war.
So now I just collect anything that interests me, but it's usually high end stuff from HOFers. Such as what i have now- a T3 Cy Young, 1947 Bond Bread Jackie Robinson, '33 Goudey Ruth, T206 Mathewson/Cy Young and a few others like e91 Wagner.
Since I'm a younger collector and can't afford really high end cards right now, I hope to acquire some big name cards like a 1933 Goudey lajoie, e107 Wagner or maybe even a baltimore News Ruth someday.