For historical significance, the most important single hit to me was 715.
For me personally (see my avatar), it was Ozzie's LCS game 6 walk-off homerun off Niedenfuer, watching after school as a 14-year old boy (ahhh, playoff games in the daytime...). He was 0 for 3,009 hitting bombs from the left side of the plate in his career! I recall NBC had posted that stat just before the hit...
Of course, Don Denkinger's blown call in Game 6 basically gave the Series to the Royals, keeping this hit from being legendary to more than just us Ozzie fanatics