My wife's from there so I get down there a couple times a year.
There's a great antique mall on Magazine street. Neat area as well to poke around. In my experience, there are a bunch of antique shops etc. with some neat items but no card shops to speak of. I think you'll do better finding ancillary items like advertising and packaging, maybe a photo or some memorabilia rather than cards specifically. Watch out for repro Piedmont signs, etc. which I also see a bunch of when I go there.
Last time I was poking around in a shop and found a 1909 LSU yearbook. The guy wanted $200 for it but was a nice piece with a leather cover in good shape. Stuff like that. Good luck and let us know if you turn up anything.
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