I'll chime in a common phrase around here, buy the card and not the holder. There are some extremely nice cards in lower grade holders and some not as nice cards in higher graded holders.
Typically you will pay more for a really nicely centered, nicely registered, nice color, nice corner card, regardless of the number on the flip.
In my opinion, I'll buy a 2 if the card is nice. But, I don't compete in the registry game so if that's your thing than the holder and grade will matter more.