Like most who have weighed in, I like to try to match the medium with what the card would most likely have been signed with during the day. Although I am not a big fan of pencil autographs, the Ott card below was most likely signed during his playing days like the Lopez which is signed in fountain pen. For the Maris card, I waited until I found an ink signed one passing on a few Sharpie signed ones beforehand. Finally for most anything 1980 and on only a Sharpie will do.