Keep in mind this is my personal "Mount Rushmore" so I am a little bias on this subject:
1. M 101-4/5 Ruth Rookie: It's not my intention to spark the 1914 News vs the M 101/4-5 Ruth rookie debate

. But it is my choice because he is in a Red Sox uniform.
2. E107 Cy Young: Again with Boston AL.
3. T-206 Walter Johnson Portarit: As mentioned above, what a great looking card and I have more respect for the Big Train after doing a lot of reading about his "Wiesner Wonder" days. What a gentleman.
And T-207 Bushelman! Just kidding but boy this one has been tough for me.
Anyone got one?
4. 1952 Topps Mantle: I don't own one but wouldn't mind. I remember in April 1980 standing at the front of the stage in St Charles, MO (St.Louis, Holiday Inn) as a kid as they "instant auctioned" a 52 Mantle. There was a hush in the room because the card had just set record prices a month or so earlier in Philly.