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ChrisAfter many years building sets, buying, selling and trading, I believe this is an accurate list of high number difficulty. In order from most scarce to easiest to find. In EX condition or better.
1949 Leaf
1952 Topps
1949 Bowman
1950 Bowman Low Numbers
1966 Short Prints
1967 Short Prints
1961
1953 Topps Short Prints
1957 Mid Series
1953 Bowman Color Mid Series
1951 Bowman
1962
1952 Bowman
1955 Topps
1963 Mid Series
1958 Low Numbers
1959
1960
1964
1965