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Paul SLike the rest of you, if it's a good design and fits the image, do it!
However, here's this lefthander's dilemma with horizontal format: Sometimes I "thumb" through a group of cards -- you know, taking a stack in one hand and using your thumb to push them into the other hand. (yes, they're in baggies or toploaders...usually 
) However, if the card numbers on the back have been lined up correctly, then horizontal cards usually end up turned around 180* and facing away from me, i.e., the picture/text is upside down (us southpaws thumb opposite handed from you righties.) On sets with mostly horiztonal formats this is somewhat easily remedied, but for sets that mix it up it is a big annoyance. If I change the offending cards around to face me then I can't search by card number easily, as the number is on the bottom! Especially annoying when they are in card boxes. Anybody else experience this? Trite, I know, but I needed to get this off my chest.