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NickMA friend of mine has family in Plaquemines Parish, LA. After 2 years of fighting, their insurer paid out over $300K on the sports collectibles rider from their insurance policy due to Katrina leveling their house. They're still fighting on other riders.
I don't know if they had major graded cards that were lost or destroyed - the only items my friend mentioned to me were Ruth and Gehrig signed balls and a personalized signed photo of the husband with Pistol Pete, but I wouldn't be surprised in the slightest if there were lots of graded cards in the mix.