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JimBFor me, it would really depend on the set. If it were T206, a set where the whole range of grades are more or less readily accessible, why bother filling a hole with a poor card if you are going for a vg set? A vg example (or 10 of them) will be available before long. On the other hand, on tougher sets, when just getting the card at all can be challenging, I am much more flexible. My e94 set has several SGC 10s, 20's, and 30's even though one day I would like it to average more in the 40-50 range. Having a few duplicates around from upgrades also gives you good trade bait.
Best,
JimB