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fkwIMO The very rare D350-3 cards are related to the newly discovered 1921 Herpolsheimer cards far more than either E121 set. There are cards (Dave Davenport for example) found in the D350-3/Herpolsheimer sets that are not known in E121.
The D350-3 cards are more for the type collector, since putting together a D350-3 set would be extremely tough if not impossible.
And if you were crazy enough to try for the set...... you have to remember there are 2 different backs (different wording) in the D350-3 cards as well