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JKIt depends on the set and your budget. When I was originally putting together the e93s, I wasnt so choosy but always anticipated upgrading the HOFers as I went along. The thing I didnt anticipate (since I really dislike spending money on commons) was that Ive also upgraded the commons because I want the set to have a consistent look. Ive now upgraded some of these cards as many as 4 or 5 times.
Im now trying to put together a much more difficult set. Im guessing I will generally have to collect the cards in whatever condition I can find them in.