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BenDan has a good point about editing your lineup daily. I might only add that one should be mindful of the "maximum games played" counter in the bottom left area of your roster page. Each offensive position has a maximum of 162 games played (and there's a maximum of 1250 innings for pitchers). I've seen many a fantasy season go down the drain because a manager started all their players for every game and went over the limit towards the end of the season.