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Brian H (misunderestimated)Andrew's top 10 (except Speaker) all made my top 15.... I agree with his point on Sisler as well. I also gave repesetation to the current crop of hitters, regardless of whether or not hey benefitted from "unfair enhancement." Nonetheless Barry Bonds was the only one on my list that I have ever really heard accused of having an unfair advantage. Frank Thomas has never been seriously accused of steriod use to my knowledge.
http://www.baseballreference.com/s/sislege01.shtml
clearly a top notch hitter -- especially in his best seasons but, his On Base percentage + Slugging average (The stat gurus call this an "OPS") was, in the context of his era (this is called the "OPS+ Adjusted" with 100 equalling the average for the season), not on par with Honus'.
http://www.baseballreference.com/w/wagneho01.shtml
As the links above show, Sisler's best OPS+ Adjusted was 181 in 1920 and Honus' was 205 in 1908. This means basically that in 1920 Siler was 180% of the league average in 1920 and Wagner was 205 % in 1908. Because of era (i.e Babe Ruth et al) Sisler never led the league in OPS+ while Wagner did it 7 times between 1900-1909.
Babe Ruth, still the all-time king in this category was 1st in the league 13 years in a row starting in 1918. Ruth's lifetime OPS+ is still the only one over 200.
http://www.baseballreference.com/leaders/OPSplus_career.shtml
The top season ever: Barry Bonds 275 in 2002 (Bonds also placed second with 262 the year before).
http://www.baseballreference.com/leaders/OPSplus_season.shtml
Additonally Sisler didn't dominate nearly as long as Wagner (not many did). Sisler, unfortunately, suffered an eye injury or something that brought him back from the realm of the "truly great" to the merely "good" after 1922. In fact he missed the entire 1923 season recuperating.