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Marc S.I've even heard of stories of auction houses literally unstitching baseballs where an autograph was on the other panel and re-stitching it with a contemporaneous unsigned panel to "voila" give you a single-signed ball of some major period superstar.
Just like anything else in life - follow the money, and you'll find exceedingly creative [and often disturbing] methods to achieve that end where the money is. Easier in cards - but in many aspects of this hobby [and most other hobbies]
~ms