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WesleyPSA has created a separate registry set for what they consider to be the top ten cards in the entire hobby. The list is considerably different than the ones that forum members have created, but the ten cards that PSA has chosen probably represents the "Holy Grail" for most hobbyists. Here they are:
Top Ten Baseball Card Classics
1909-11 T206 TY COBB
1909-11 T206 EDDIE PLANK
1909-11 T206 HONUS WAGNER
1915 CRACKER JACK JOE JACKSON
1933 GOUDEY BABE RUTH
1933 GOUDEY NAPOLEON LAJOIE
1934 GOUDEY LOU GEHRIG
1948 LEAF SATCHEL PAIGE
1952 TOPPS MICKEY MANTLE
1954 WILSON FRANKS TED WILLIAMS