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ScottI said that the "big 3" aren't capable of detecting alterations such as re-coloring, glueing tears, adding paper. I actually believe that all three are capable of detecting any such alterations;the problem is that although the technology is available, it obviously isn't cost-effective to go to the trouble of looking that closely at ALL cards. Perhaps trimming is a different issue - others can speak to this.
All I would ask is that the major grading companies at least have access to the tools necessary to spot such alterations, and to USE THEM for high-profile cards (big name HOF'ers such as Ty Cobb, and cards with high book values).
If someone out there thinks it's actually true that the technology does not exist to spot all re-coloring, glueing, corner build-up, let us know - that's some information we should all be aware of.