(George) Washington, who was lieutenant colonel in the newly created Virginia Regiment (
My Note: At the tender age of 22! 
), set out on April 2, 1754, with a small force to build a road to, and then defend, Fort Prince George. Washington was at Wills Creek in north central Maryland when he received news of the fort's surrender. On May 28, Washington encountered a Canadian scouting party near a place now known as Jumonville Glen (several miles east of present-day Uniontown).
Washington attacked the French Canadians, killing 10 in the early morning hours, and took 21 prisoners, of whom many were ritually killed by the Native American allies of the British. On May 31, Washington replaced Colonel Joshua Fry as commander of the Virginia Regiment after Colonel Fry died en route to Wills Creek.
The Battle of Jumonville Glen is widely considered the formal start of the French and Indian War, the North American front of the Seven Years' War.
Washington ordered construction of Fort Necessity at a large clearing known as the Great Meadows. On 3 July 1754, the counterattacking French and Canadians forced Washington to surrender Fort Necessity.
After disarming them, they released Washington and his men to return home.
Although Fort Duquesne's location at the forks looked strong on a map—controlling the confluence of three rivers—the reality was rather different. The site was low, swampy, and prone to flooding. In addition, the position was dominated by highlands across the Monongahela River, which would allow an enemy to bombard the fort with ease. Pécaudy de Contrecœur was preparing to abandon the fort in the face of Braddock's advance in 1755. He was able to retain it due to the advancing British force being annihilated (see below). When the Forbes expedition approached in 1758, the French had initial success in the Battle of Fort Duquesne against the English vanguard, but were forced to abandon the fort in the face of the much superior size of Forbes' main force.
The French held the fort successfully early in the war, turning back the expedition led by General Edward Braddock during the 1755 Battle of the Monongahela. George Washington served as one of General Braddock's aides. A smaller attack by James Grant in September 1758 was repulsed with heavy losses.
Two months later, on November 25, 1758, the Forbes Expedition under the Scotsman General John Forbes took possession Fort Duquesne after the French destroyed and abandoned the site.