Kind of exceptional circumstances, but when Cobb was suspended during the Leuker incident (known as the Suspension Game),
https://en.wikipedia.org/wiki/Detroi...enter%20field.
Cobb's replacement player for the game on May 18, 1912, Willaim Leinhauser made 4 appearances at the plate, striking out 3 times. Per SABR, "...when Leinhauser's wife found that he had the audacity to replace the great Ty Cobb, she hit him with a skillet."