To reduce my collection from filling an entire room to only filling a closet. Been working on this one for years. With some pretty good success.
For cards I wouldn't mind getting another 1952 Topps Eddie Mathews rookie. It is one of the few cards I regret parting with. A T206 Red Cobb with Old Mill back. Had the Cobb before but Piedmont back. The expensive one is the T210 Joe Jackson so I have all the players with the last name Jackson from the set.
In memorabilia I would love a Wade Boggs minor league or rookie bat to add to my meager Boggs bat collection. I only collect Boggs bats but wouldn't mind adding a Roger Clemens and a Tino Martinez bat to my lone Eddie Mathews Spline bat so Eddie stops feeling lonely and outnumbered 39 to 1.