Depends on your goals. If you are picking nits over condition, or trying to get a raw card into a PSA 8-9-10 slab, you have to be concerned. If not, it is purely whatever you find appealing. I look for minty o/c cards with the o/c being the back. Some of my favorite cards are like that and I bought them for far less than their better centered cousins as a result.
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