Simple supply and demand
As noted in a number of posts - there are many cards even of Wagner (Look at Ryans post for a nice selection!) that are much rarer (in lower supply) than the T206. That said, the one thing that the T206 set and the Wagner, in particular, have over all those other cards is exponentially greater demand! So there may be 57 or 67 or 80 Wagners, but there are many more than that number of people apparently with both the desire and the means to acquire it and the price continues to be driven up.
Many of the super rare (less than 5 known copies) are so obscure most collectors don't bother looking = lower demand and hence lower price relative to the T206 Wagner.
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