Finishing Series 1 is tougher than it is deemed. I found, overall, Jacksonville was a tad tougher than other teams. But, as TBob says, there are some real toughies out there. However, never really knew Lee, Macon was one (added him to my five top toughs). BTW, that's brutally sad "Lee" situation, stinks....
My Tough Ones (and maybe reasons why):
Viola -- Same player as misspelled T206 Violat. Maybe the T206 connection, or him being one of the earliest Latin players. I "think"

he is THE toughest.
Schwietzka -- Don't know. Maybe the same reason he is one of my favorites: Great name and pose.
Manion and Lipe: Same, possible T206 (T211 ?) connection.
"Oyster Joe" Martina -- Rookie card of a player with long (20+ years) minor league experience, and "odd" late career appearance with World Champion 1924 Senators.
Lee, Macon -- ??????
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It is a great set to pursue. Yeah, 610 isn't terribly realistic. BUT, you can collect them any way you want --- team, series, region, etc........
Fun stuff, Scott