Depends on the set. Many vintage sets came out in series - take for instance the 1914 Cracker Jack cards. #1-72 came out first as the low number series, and #73-144 came out later as the high number series, and are more scarce.
What numbers and how big the series are varies with every set. For the 1952 Topps, #1-80 are the low numbers, #81-310 are mid, while the high numbers are #311-407 and are the toughest. For 1957 Topps, the toughest cards are from a middle series. So it can vary every year.
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