With the way prices are going I think a small wrinkle/crease (as long as it still has eye-appeal) will become more accepted. Personally I am ok with a small crease or spidering if the card still has good eye-appeal. My Aaron rookie as an example. The tiny crease on the left side almost half-way down is hardly noticed and some denting on the bottom corners does not take away from the eye-appeal to me. I'm sure those flaws might really bother some collectors but with the way HOF rookie cards are exploding in price I think collectors will be willing to live with the imperfections of a crease.
