I know some people seek to collect entire sets of autographed cards. With that in mind, I ran across these four random signed cards from the 60's in my collection:
1961 Topps Bobby Gene Smith, #316
1961 Topps Gene Mauch, #219
1964 Topps Johnny Klippstein, #533
1965 Topps Mickey Lolich, #335
I have no 'official' provenance as to where they came from, but there's nothing to suggest that these signatures aren't legitimate.
If you're interested in trading for any of these guys, my need lists are floating around in virtually every thread I start, so LMK what you have. Also, check out the 'autographs' section of my bucket. I have a wide variety of stuff there that you might be interested in, too.