I've done it. In fact I just got a John Cleese from a book signing that I will be removing and having made into a custom card, like my Eric Idle. I wanted to read the book anyway, so I figure I got a great autograph for free!
I remove it as carefully as I can, then square up the ragged binding edge with a cutter I have at the office. When I decide what to do in terms of custom cards, etc., it is ready to go.
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