Leon is absolutely correct. There are tons of cards rarer than the Wagner (including, I would guess, my Plow's Candy below), but few or none that have the Wagner T206 combination of
1) top 10 Hall-of-Famer
2)hugely popular card series (T206)
3)scarcity
4) interesting back story (the whole tobacco thing, whether true or not).
Not to mention famous owners, such as Gretzky.