Joss died of tubercular meningitis. This means he had tuberculosis for a period of time prior to it moving to his central nervous system. In the past, TB was called consumption by the general public. This is because the body's resources are "consumed" by the illness. It could have easily caused a healthy person to waste away. Unfortunately, Joss wasn't anywhere near healthy. He also suffered from malaria during this time period. Even with modern medicine, recovery from either of these things is not assured. Recovery then was about luck.
I'm sure this is all part of why he looks like that
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