Probably don't have much to add to what has been said, but I have sold quite a bit of art through auction houses.
Is your six figure number for a single piece or the cumulative total? Sotheby's and Christies in particular will generally give you the run around on single items less than $50k.
Just like cards, know your audience and pick the auction house that best matches the item. While the big boys above are big boys for a reason they are often not the best venue. Illustration or Texas art will likely do much better with Heritage. Americana does very well with Cowan's. Philips and Bonhams are both very good for contemporary works and have international reach.
Talking of International. If your work(s) ends up in an international sale, say the UK or Japan, be aware of tariffs that might apply.
Regarding fees, the smaller (not small) houses are more likely to waive fees if it can be a signature item in their auctions. Being smaller does not necessarily mean less of a hammer price, just like with cards.
Good luck with this.
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