Ryan,
My answer to questions like this is always to try to buy the Hall of Famers and any high-demand or short-print cards first, for the simple reason that if you end up bailing on the set, you're going to find it easier to get all or at least most of your money back with Hall of Famers than commons.
And if your budget allows it, try to avoid beaters. Although there is absolutely nothing wrong with collecting off-condition cards and many people truly enjoy them, the fact is that you'll be selling to a much smaller market if you offer rougher-looking cards.
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