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Steve M.Built T206 (minus big 4)...broke it up...started over, now about 41% there.
Built 59 Topps...sold big boys...no particular regret there.
Built C46...now that was a challenge...sold it for $1,500 about ten years ago...regrets there.
Started now on 1911 and 1912 Zeenuts...if I don't find a Z11 Bohen soon maybe I'll get bored 
My Sporting Life W601 PC set needs one to complete...while I am frustrated that I have to wait for Dan to die to get the final one I WILL NOT SELL.
Same with my Ullmans...Need 3 to complete...been at it for easily ten years...No intention of selling.
Frustrated, no. I think Gil has it right. Just set it aside if your interests have changed. Then likely, as with my T206 experience, you may have a renewed interest and no regrets.