The cream will always rise. The best cards (or memorabilia) of the best players, will always be considered "blue chip" material, and will always be in demand. Obviously they'll be peaks & valleys, but the better/best items will hold their value.
In addition to vintage, I think this can/will hold true for more contemporary items, such as important game used bats (Jeter, Trout, etc), uniforms, and some very limited production cards.
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