I start with low offers quite a bit. You never know, sometimes they're accepted. I hate it when a seller doesn't respond at all. Just send a "sorry, I can't budge" or "this is my bottom dollar" note so I know where you stand.
As a seller I always set the auto accept/decline options so I don't have to fool with it. As a buyer I prefer that as well so I don't have to wait for a response.
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