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Scott TI have 460 cards and "attacked" the set by buying commons first. I am now down to five commons and have also managed top pick up a decent amount of Southern League cards and HOFers.
Barring a winning lottery ticket, I know will never finsh the entire set.
Some collectors would rather just have a few HOF cards in mid to upper grades. Personally, I would rather have a larger assortment of lower grade common cards. (I think it adds a sense of flavor to the set.)
In the end, it will be your decision, so do what you think is best.
Scott