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Anthony N.I think so.
According to Lipset, Phil AL, Boston AL, NY NL, Brooklyn, Cleveland and Cincinnati are "unusually common"
Cubs, WhiteSox are "moderately more difficult". He rates NY AL and both St. Louis teams, along with Boston AL as more difficult, with NY NL and St Louis AL the toughest. I'd disagree on this last part, as I feel Boston NL is the toughest card in the set, with NY AL and the Browns a bit easier, and the Cards a bit easier still.
I've never seen a reason for any of this.
edited to fix typo.