As for TPG's and the plastic, I think they'll always be necessary especially for prewar. I think I have a fairly good idea about grading, but I have a hard time authenticating cards (see my posts asking if various cards are authentic). I know the general rules for authentication, but if it's a higher value card, I sleep a lot better at night if I know a reputable TPG has authenticated the card. This is the same with altered and trimmed (and rebacked) cards, I am not good at seeing this unless it is really obvious.
Regarding registries, I think they are a really good checklist function as others have mentioned. This is really useful if you are a master player set collector, as the registry can help you figure out the wacky cards for the player you are missing.
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