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PaulI'm not sure it's pre-war, or a "card", but George Kell's 1945 team issue with the A's is quite tough. So is the 1948 Safe-T card of Early Wynn with the Senators. That's Wynn's first card, but 9 years after his debut, so it's tough to call a rookie card. Of course, none of this compares in rarity to Ryan's psychotic stuff.