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warshawlawExpense isn't the only factor. For my cards, if there is anything over $300 and an untried seller, I send the seller a fed ex package on my account and ask the seller to use it to send me the card. I also do it for cards that I really want to be sure I get, even if they are not that expensive. For example, I really needed one card from a very tough boxing set. I got it for less than $200, but from a novice seller, so I sent the seller a Fed Ex package with shipping materials.
When I sell, I generally leave it to the buyer's discretion up to $500. Anything more, I insist on Fed Ex shipping.
When I submit to a grader, I always send them Fed Ex. The incremental cost per card just isn't that great versus registered mail, and it is like using a power tool instead of a flint axe in terms of responsiveness, reliability and tracking.