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Brian H.We can all think of numerous specific cards that defy the guides (e.g. T207 Weaver & Wood). The guides do a very good job in general -- especially with the stuff that most people buy them for (cards less than 50 years old).
However, vintage cards -- especially the more obscure ones -- generally are difficult to price. They don't pop up that much and when they do its not always in the same condition. Our little eccentric vintage portion of the guide is best used as a checklist and as a starting point for pricing.